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Serious but rare side effects include pancreatitis (severe abdominal pain that radiates to the back), gallbladder issues, and acute kidney injury

All mechanistic discussions remain observational and exploratory in nature and are strictly limited to non-clinical laboratory research environments

Some improvement in symptoms may be seen within a few days to a week after starting treatment, but it can take longer for more severe symptoms to resolve

Overall, these studies demonstrate that lipolysis signals a homeostatic response by providing ligands to nuclear receptors to regulate gene expression and thereby modulate cellular metabolism (Figure 3)